(440f) Pharmaceutical Bio-Applications of Nanocomposite Layers On Drug Carriers

Interactions of nanocomposite layers on active pharmaceutical ingredients and their carrier materials during pharmaceutical formulation and mixing process have been investigated with a focus on bio-applications related to drug release and bioavailability. The influence of loading of nanocoating related to contact hardness, adhesion force and nanoporosity was studied in order to understand the bio-availability of drug component. Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Inductively Coupled Plasma Mass Spectroscopy (ICPMS) and Atomic Force Microscopy (AFM) were used to characterize the nanocomposite layers deposited on particle surfaces. Nanosurface studies performed using atomic force microscopy (AFM) showed that the topography of nanostructures changed considerably based not only on the type of contact (low contact, medium contact or high contact), but also on the % contact area. In addition, it was found that the thermal interaction at nanoscale played a crucial role in controlling the nanoporosity of nanolayers, thereby increasing or decreasing the adhesion force between two drug or excipient particles. ICPMS studies confirm that the nanocomposite structures formed on particle surfaces control the mixing at nanoscale thereby resulting in the formation of new nanostructures at the inter-particle interface. Force distributions on homogeneous and non-homogenous layers showed that the adhesion force on the particle surface is non-uniform depending upon the topography of nanostructure. We expect that these variations in uniformity in loading which controls the drug release pattern have wide applications in biomedicine.