(593ax) Utilization of Drop-On-Demand Technology in the Manufacture of a Novel Nicotine Transdermal Patches

The skin represents an ideal avenue for transport of APIs to obtain enhanced functional and therapeutic effects; however, the successful application of transdermal drug delivery systems remains limited and faces many challenges. To address this issue, we utilize Drop on Demand technology to construct API formulations and polymer films creating personalized transdermal patches with controllable architecture.  As result, one can increase the dissolution rates of API(s)  by creating a novel drug-in-adhesive layer, negating the need for a separate adhesive layer for use in transdermal delivery.  We propose to create distinct transdermal dosage forms where (1) the adhesive is printed adjacent to the API droplet (2) the interdroplet spacing and volume of the API droplet is varied, and (3) two different drugs & adhesive will be printed onto the same layer. Additionally a mathematical model using partial differential equations  was developed to examine the flux of a drug through the layers of a traditional transdermal patch compared to the modified patch developed using Drop on Demand technology.    We found that the flux of the drug in our modified transdermal patch was much greater as compared to a traditional patch where the drug was immersed in adhesive (drug in adhesive patch) or where the adhesive layer was completely separate from the drug layer.