(216aq) Fabrication of Functionalized Parylene Particles Based On Electrospinning

Fabrication of Functionalized Parylene particles Based on Electrospinning  

Hsin-Ying Ho^a and Hsien-Yeh Chen^a*

Department of Chemical Engineering, National Taiwan University, Taipei 10617, Taiwan

E-mail: hsychen@ntu.edu.tw

Abstract

Functionalized poly-p-xylylenes are synthesized via CVD polymerization from substituted [2.2]paracyclophanes, and these functional coatings have recently been introduced as powerful interlayers that can flexibly decouple surface properties from bulk materials to achieve biointerface engineering on a variety of substrate materials.

Those coatings are belong to the parylene family, or may be referred to as “reactive coatings,” have been reported to possess all of the advantages of their commercial siblings, and in addition, provide versatile anchor groups for sophisticated surface modifications to mimic biological functions. More attractively, a library of functional groups including amines, alcohols, aldehydes, anhydrides, activated carboxylic acids, activated esters, maleimides, and alkynes, have successfully been equipped on these polymers and used for performing manipulations on biotins, proteins, saccharides, DNA, hydrogels, polymers, enzymes, and cells. In this study, functionalized poly-p-xylylenes synthesized via CVD are verified by infrared reflection absorption spectroscopy (IRRAS) technique. Subsequently, electrospinning is performed at relatively low polymer concentrations to produces functionalized poly-p-xylylene particles. Two characterization method, scanning electronic microscope (SEM) and photon correlation spectroscopy, are then used to measure particle size distribution. We foresee the reported functionalized poly-p-xylylene particles may find important applications in developing sophisticated biomaterial.