(310c) Development of Automated Cell Processing System for Clinical Application

In the last decade, cell and tissue therapies have encompassed a broad, rapidly growing field of medicine that involves the manipulation and administration of cells for the treatment of disease. Especially, the advances in tissue engineering have offered promising strategies for reconstructing and repairing defective tissues in vivo, enabling damaged tissue to be replaced with cultured tissues that meet the needs of the individual patients.

In the present study, the comparison of management between cell processing facilities with safety cabinet and with the isolator system reveals that isolator technology leads to reductions of the running cost as well as operational laboriousness in the small production, compared to the conventional clean room facility with safety cabinet. In addition, a novel design of manufacturing facility based on a flexible Modular Platform (fMP) has been proposed to realize that the individual modules can connect and disconnect flexibly with keeping the aseptic environment as well as biological containment in each module, leading to the compactness of aseptic processing area and quick change-over for multi-purposes and patients. This technology will make cost-saving with safety and security.