(515j) Impact of Tablet Solid Fraction On Disintegration Rate
AIChE Annual Meeting
2013
2013 AIChE Annual Meeting
Engineering Sciences and Fundamentals
Solid-Liquid Interfaces II
Wednesday, November 6, 2013 - 2:45pm to 3:00pm
The absorption rate or extent of absorption of an active pharmaceutical ingredient (API) in patients can be significantly affected by the time required for a tablet to mechanically disintegrate in the stomach. Depending upon the dosage form, tablet disintegration times can be designed to range from tens of seconds for orally disintegrating tablets to several hours for extended release tablets. Tablet composition is critical to controlling the disintegration rate. However, even for a fixed composition, the disintegration rate can be significantly impacted by the size and porosity of the tablet. In this work, a mathematical model is derived to relate tablet disintegration time to tablet thickness and porosity. Experimental data are queried from electronic lab notebooks using proprietary internal software and used to assess the validity of the disintegration rate model. Tablet compaction profiles are analyzed and results are presented from over 400 batches of tablets.