(601a) Optimized Synthesis and Characterization of Silica-Cellulose 3,5-Dimethylphenylcarbamate Hybrid Spheres and Investigation On Its Enantioseparation Ability On Beta-Blocker Drugs

The current commercial chiral stationary phases mostly rely on the coating and immobilizing effort to be fixed on the macroporous silicon spheres, which leads to a low loading capacity and lack of enough mechanical strength, limiting the further industrial preparation in a large scale. Synthesis of silica-cellulose 3,5-dimethylphenylcarbamate hybrid spheres adopting sol-gel method could effectively enhance the loading capacity and mechanical strength of packing material as chromatography packing material, aiming at the ultimate industrial application of preparative column and Simulated Moving Bed etc. However, a detailed and comprehensive characterization is still in the need to optimize the preparation condition to obtain a more applicable hybrid material. During the investigation process of optimization, an end-capping treatment is adopted and proved to be one indispensable factor to improve the enantioseparation ability and applicability of packing material. Otherwise a serious absorbance aroused by residual hydroxyl groups such as peak tailing may occur, making it totally impossible to separate racemates with certain polarity. A careful characterization and discussion is conducted to investigate the effectiveness of end-capping treatment as well as the overall property of hybrid material. Beta-blocker drugs belong to the family of basic drugs with pharmaceutical and commercial value, effective enantioseparation of which is meaningful and important. By end-capping most of residual hydroxyl groups of packing material, we are able to obtain hybrid material with ideal chiral recognition ability and enough mechanical strength, the resolution of β-blocker drugs on the end-capped material is also effective and of potential value for industrial applicability.