(692a) Controlled Plasmonic Coupling of Multifunctional Gold Nanoparticles for Photothermal Cancer Treatment
AIChE Annual Meeting
2013
2013 AIChE Annual Meeting
Nanoscale Science and Engineering Forum
Nanotechnology for Biotechnology and Pharmaceuticals II
Thursday, November 7, 2013 - 12:30pm to 12:50pm
Plasmonic nanoparticles show great potential to the in-vivo photothermal ablation of tumors because of their efficient near-IR light-to-heat conversion. Here, we show that by finely tuning the plasmonic Au nanoparticle coupling of those nanoparticles the optical absorption can be also finely controlled, broadening it to the near-IR spectral region. Hybrid plasmonic-superparamagnetic nanoparticles are encapsulated in-situ during their gas-phase synthesis by a nanothin, smooth silica coating with a precise control over the coating thickness [1,2,3]. This fine control of the interparticle distance within each agglomerate enables such hybrid bionanoprobes to efficiently convert light-into-heat upon their near-IR irradiation and facilitates their employment as efficient therapeutic agent in photothermal heat tumor ablation. The feasibility of such multifunctional [4] gold nanoparticles as efficient plasmonic photothermal agents is demonstrated by destroying breast cancer cells in vitro upon near-infrared laser irradiation.
References
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[4] Sotiriou G. A., Biomedical Applications of Multifunctional Plasmonic Nanoparticles. WIREs Nanomed. Nanobiotechnol. 5, 19-30 (2013).