(119e) Prediction of Feasible Operating Region for an Integrated Set of Unit Operations
AIChE Annual Meeting
2015
2015 AIChE Annual Meeting Proceedings
Pharmaceutical Discovery, Development and Manufacturing Forum
Application of Quality by Design in Drug Substance Process Development
Monday, November 9, 2015 - 2:12pm to 2:36pm
Title: Prediction of Feasible Operating Region for an Integrated Set of Unit Operations
Authors: Carla Luciani, Salvador Garcia, Kevin Seibert, Thomas Wilson, Eric Crick
In this work, the prediction of feasible operating regions for a set of integrated unit operations will be discussed. Particularly, three unit operations will be investigated: a Suzuki coupling reaction, a liquid-liquid extraction, and metal removal in a series of continuous adsorption columns. The prediction of the feasible operating region is aided by a mechanistic model built.