(601e) How Nanostructures Affect Cell Behavior?

A growing body of literature shows that certain nano- to micron scale surface features or surface patterns can modulate cell behaviors in vitro and in vivo, suggesting the potential for enhancing biomaterial and device functions in vivo. In recent years, a variety of techniques has been developed to create random or patterned nano-to-micron scale features on the surface of biomaterials, including metals (e.g., titanium), polymers (e.g., biodegradable polyesters), and biocomposites. Distinctive cellular behaviors on nanostructured or microstructured surfaces have been observed and reported. This talk will discuss current methods for creating these features on biomedical device surfaces and their respective effects on cell adhesion, proliferation, and differentiation, as well as their potential for clinical translation. Special attention will be given to recent results on stem cells and bacterial cells.