(624h) Development of a Challenging Salt Formation Step for a Phosphate API
AIChE Annual Meeting
2015
2015 AIChE Annual Meeting Proceedings
Pharmaceutical Discovery, Development and Manufacturing Forum
Poster Session: Pharmaceutical
Wednesday, November 11, 2015 - 6:00pm to 8:00pm
The development of a final API step involving salt formation is described. Challenging properties of this system include: (1) the free base API has low solubility in most organic solvents; (2) residual solvent is difficult to reduce below desired limits; (3) salt disproportionaton occurs at mild temperatures. A process that addresses these challenges was developed, generating API with desired physical properties.