(726g) Recognition of L-Amino Acid at Liposome Membrane Surface and Its Application for Homochiral Polymerization
AIChE Annual Meeting
2015
2015 AIChE Annual Meeting Proceedings
Materials Engineering and Sciences Division
Biomolecules at Biomaterial Interfaces
Thursday, November 12, 2015 - 5:03pm to 5:21pm
We report the enantioselective adsorption of an L-amino acid on an L-form liposome and amino acid polymerization on the liposome. L-form liposomes are involved in the enantioselective binding and concentration of adsorbed L-amino acids, and protect activated intermediates from hydrolysis. The use of L-form liposomes therefore enables homochiral polymerization and more efficient polymerization of L-amino acids than of D-amino acids. Our developed method can therefore be used for the synthesis of homochiral biopolymers from racemic monomers and could be helpful in understanding prebiotic biopolymer formation.