(259i) Surface Modifications of Superparamagnetic Iron Oxide Nanoparticles with Polylactic Acid-Polyethylene Glycol Diblock Copolymer and Graphene Oxide for a Protein Delivery Vehicle | AIChE

(259i) Surface Modifications of Superparamagnetic Iron Oxide Nanoparticles with Polylactic Acid-Polyethylene Glycol Diblock Copolymer and Graphene Oxide for a Protein Delivery Vehicle

Authors 

Doan, L. - Presenter, Lamar University
Phan, V., Lamar University
Cocke, D. L., Lamar University
Palanki, S., Lamar University
Wujcik, E. K., Lamar University
Superparamagnetic iron oxide nanoparticles (SPION) have been used in the biomedical industry for such applications as magnetic resonance imaging (MRI) contrast agents or drug delivery for a number of years, however, none have included the use of graphene oxide as a protein/drug carrer or for reporting. In this study, after using a co-precipitation SPION synthesizing method, SPION is coated with polylactic acid-polyethylene glycol (PLA-PEG) diblock co-polymer through emulsion polymerization. The SPIO-PLA-PEG NPs are then coated with single layer of graphene oxide (GO). The biocompatable NPs can then be hydrogen-bonded surface coated with various proteins, without affecting the confirmation or active sites of the porteins.