(551e) Scaling Intra-Tablet Coating Variability
AIChE Annual Meeting
2016
2016 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Predictive Scale-Up/Scale-Down for Production of Pharmaceuticals and Biopharmaceuticals
Wednesday, November 16, 2016 - 1:58pm to 2:20pm
Pharmaceutical tablets usually exhibit variability in coating thickness, both across individual tablets as well as over a single tabletâ??s surface. In this work, the coefficient of variation in coating thickness, referred to as intra-tablet coating variability, is examined as a function of processing scale. The discrete element method (DEM) is used to simulate the dynamics of two different tablet shapes in coating pans of four different sizes. The asymptotic intra-tablet coating variability is observed to increase with increasing pan size. Studies designed to explain the observed trend are also presented.