(570g) Invited Presentation: Sensor Technologies for High Throughput Bioprocess Monitoring

Dr. Raoâ??s research has focused on applications of fluorescence spectroscopy to bioprocess engineering. His lab has developed next-generation sensors for low-cost non-invasive monitoring of oxygen, pH and pCO2 in bioreactors. In addition, novel sensors for glucose and glutamine have been developed. These sensors have led to a paradigm shift in bioprocess technology, as they collectively enable High Throughput Bioprocessing. In addition, the Rao lab has focused on developing novel applications of Green Fluorescent Protein in Bioprocessing. Its unique fluorescent properties and ease of use in a variety of culture systems have provided new insights into heterologous protein production. Recently, the Rao lab has started developing the next generation of sensors based on surface plasmon coupled fluorescence. These promise to lead to ultra-sensitive and ultra-fast sensors but at low-cost.