(164c) Functionalization of Iron Oxide Nanoparticles and the Impact on Reactive Oxygen Species Generation for Potential Cancer Treatment | AIChE

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(164c) Functionalization of Iron Oxide Nanoparticles and the Impact on Reactive Oxygen Species Generation for Potential Cancer Treatment

Authors 

Mai, T. - Presenter, University of Kentucky
Hilt, J. Z., University of Kentucky

Functionalization of iron oxide
nanoparticles and the impact on reactive oxygen species generation for
potential cancer treatment

Trang Mai, J. Zach
Hilt

Department of
Chemical and Materials Engineering

 University of Kentucky Lexington, KY 40506

Corresponding
Author: zach.hilt@uky.edu

Iron oxide nanoparticles (IONPs) and reactive oxygen
species (ROS) generation have attracted much attention in the last several
years. It has been shown that IONPs can produce ROS, which play a major role in various cellular pathways, via Fenton and
Haber-Weiss reactions. Recent studies also show that alternating magnetic field
(AMF) exposure can enhance the production of ROS by IONPs. At increased level,
ROS can cause damages to proteins and
other biological structures, lead to cellular apoptosis, and contribute to many
diseases including cancer. The AMF-enhanced ROS could provide a potential
strategy to exploit the elevated ROS stress for cancer therapy.

The aim of this work was to develop iron oxide
nanoparticles based platforms with either small molecule or polymer coatings
and to study impact of the coating on the surface reactivity of the particles.
Iron oxide nanoparticles were synthesized by a co-precipitation process and
coated with small molecules (e.g., citric acid, sodium phosphate, aminosilane, dopamine) or polymers, such as poly(ethylene glycol)-based systems. Crystal and functional
properties of the synthesized particles were characterized using X-ray
diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. Hydrodynamic
size was determined by dynamic light scattering (DLS) while the amount of
coating was investigated using thermogravimetric analysis (TGA).  AMF heating ability was also demonstrated.
Surface reactivity via ROS generation induced by the particles was evaluated
using a methylene blue decolorization assay with
hydrogen peroxide and AMF exposure for varying times. 

Topics 

Nanomaterials

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