(164d) Theranostic Nanovehicles for the Diagnosis and Treatment of Cerebrovascular Diseases
AIChE Annual Meeting
2017
2017 Annual Meeting
Sustainable Engineering Forum
Nanomaterial Applications for Human Health and the Environment
Monday, October 30, 2017 - 1:24pm to 1:42pm
For successful brain delivery, any nanosystem must withstand dominant clearance pressure from the peripheral reticuloendothelial system, marginate from the bulk blood flow to the vascular endothelium, permeate the blood-brain-barrier, and accumulate at the target site. In addition to these common challenges, the nanoparticles intended for cerebrovascular targeting must incorporate appropriate design elements to ensure their retention in the cerebral vasculature. Furthermore, a functionally optimized nanovehicle design demands synergistic amalgamation of the physicochemical properties of various components and their intended physiological effects. Strategies developed in our laboratory to surmount these barriers will be discussed in the talk.