(204y) A Computational Study on the Transport of Actives through Skin Layers
AIChE Annual Meeting
2017
2017 Annual Meeting
Engineering Sciences and Fundamentals
Poster Session: Thermodynamics and Transport Properties (Area 1A)
Monday, October 30, 2017 - 3:15pm to 4:45pm
Skin is composed of many layer in series, mainly SC (stratum corneum), VE (viable epidermis) and dermis. Out of these three layers, the first layer, SC, is responsible for barrier function of the skin. The SC is made up of corneocyte and lipid matrix, which are arranged in brick and mortar fashion respectively. Dermis consists of microscopic blood vessels through which drug enters into systemic circulation.
The detailed modelling of all the skin layers would give an insight into the transport mechanism of drugs in skin layers and would help in obtaining the desired total drug uptake. In this study, we have integrated the models of all the skin layers, and performed finite element simulations to obtain the dermal uptake. The heterogeneity of SC was captured using bricks and mortar model, the diffusion coefficient which governs the transport process in SC was obtained accurately from molecular dynamics simulations1 instead of depending on experiments or from fitted data. The VE layer and subsequent dermis layer were approximated with compartmental models. Diffusion coefficients of the drug in the VE and dermis were obtained from available empirical correlations.2 Finite element method framework was used to predict the time and space dependent concentration profiles of drug in different layers of skin. Permeation of the drug in all these layers were linked in the integrated model. The model was validated with experimentally available release profile.3,4 The concentration depth profiles in VE and dermis layers were also compared with the available experimental data. Our integrated model provides flexibility in analyzing diffusion process in individual skin layers as well as whole skin. This model shall be used as guiding tool for performing targeted experiments in designing a suitable delivery system.
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