(294d) Wei-Shou Hu and the Cho  ‘Omics Revolution

Wei-Shou Hu has been a pioneer and innovator in mammalian cell technology for more than three decades. He continues to act as a trail blazer in applying new technologies to mammalian bioprocessing; perhaps none more than in the area of ‘omics analyses. His approaches have been inspirational and challenged the rest of the community to “up our game for the better.” Indeed, it is upon this foundation that many researchers in mammalian biotechnology have established an improved framework for mammalian cell culture systems characterization. In Chinese hamster ovary (CHO) cells, Professor Hu was the first to apply a systems biology paradigm to enhance our understanding of this critically important cell factory. He continues to this day to implement inventive methodologies and techniques to help better describe CHO cells at the molecular level and how molecular events impact physiology and the production of complex biologics. In this presentation, some of the many important and informative ‘omics contributions undertaken by the Hu lab will be described and how they have helped the mammalian biotechnology community better understand CHO cells and apply this cell factory for biomanufacturing applications.