(367e) Cell Culture Engineers’ Influence in Cell Therapies
AIChE Annual Meeting
2017
2017 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
In Honor of Wei-Shou Hu II - 30 Years of Mammalian Cell Culture Engineering for Biologics Manufacturing (Invited Talks)
Tuesday, October 31, 2017 - 2:05pm to 2:25pm
Over the past 30 years, bioengineering has enhanced, by several orders of magnitude, the productivity and robustness of industrial-scale, stirred-tank therapeutic protein production processes. Progress continues with creative methods of process intensification and time-honored chemical engineering methods for continuous processing. It is expected that over the next decades, cell culture engineering should provide the same enhancements to industrial production of cell-based therapeutics. Cell therapies are a fast-growing and rapidly evolving and improving area of biotechnology which have the potential to provide unprecedented efficacy for devastating diseases globally. Among the many challenges in this area that cell culture engineers will tackle are high costs of goods, rare and ill-characterized raw materials (often patients’ own cells), complex supply chains, and unpredictable process performance. This presentation will highlight the influence cell culture engineers will have in addressing these challenges with parallels to the challenges of therapeutic protein production.