(56f) Nanoparticle Supported Lipid Bilayers for Drug Delivery
AIChE Annual Meeting
2017
2017 Annual Meeting
Nanoscale Science and Engineering Forum
Bionanotechnology for Gene and Drug Delivery II
Monday, October 30, 2017 - 9:30am to 9:48am
Supported lipid bilayers have been extensively explored on two-dimensional planar surfaces. Recent advances have enabled the production of supported bilayers on nanoparticle surfaces. These membranes are often the most basic of supported membrane types, which involve fusion of the membrane with the surface of the nanoparticle. This type of supported membrane is simplistic and lacks some of the fundamental properties of liposomes, such as a fluid membrane, that have been implicated in their clinical success. This work aims to produce a nanoparticle supported membrane that retains the unique characteristics of liposomes that make it one of the most highly utilized drug delivery systems. A methodology to achieve this goal has been investigated and preliminary results suggest a successful approach has been established. Material synthesis, conjugation and characterization techniques have been developed. This work lays the foundation for producing novel lipid-nanoparticle composites that have numerous applications in drug delivery.