(190bh) Procaine Loading and Release from MIL-100 (Cr,Fe) and MIL-101(Cr,Fe), and Pectine-MOF Matrice

Chronic inflammatory skin diseases are group of autoimmune disorder diseases that have no total cure yet. Almost 1-2 % of world’s population suffer from these diseases, which have negative impact on living comfort of the patients. Topical, phototherapy and orally administered drugs are conventionally used to get these diseases under control. Recently, parallel to the improvements in materials science and biotechnology, more emphasis is given on topical treatment compared to phototherapy and orally administered drugs, since they exhibit severe side effects on the metabolism and several tissues. Even in topical treatment, unconscious and drug over use may cause osteoporosis and tissue loss. All these problems have underlined the importance of the use of controlled drug delivery systems in topical treatment.

Controlled drug delivery systems primarily aim to achieve improvement in theurapeutic benefit of the drug and comfort of the patient. Controlled drug delivery systems offer several advantages such as minimizing drug degradation and drug loss, increasing drug bioavailability, increasing drug accumulation on the targeted area, and preventing toxic effect on healthy tissue. An ideal controlled drug delivery system must be biocompatible and stable in in vivoconditions. Since 2006, prominent scientists have reported the high potential of MOFs (MIL-100(Fe) and MIL-101(Fe) explicitely) in drug delivery systems, due to their high porosity and large surface area.

The aim of this study is to investigate the drug loading and release properties of nanosized MIL-100(Cr,Fe) and MIL-101(Cr,Fe). Investigation of the drug release from pectine-MOF patches. Procaine is chosen as a drug since it is known that it is used therapeutically due to its sympatholytic, anti-inflammatory, perfusion-enhancing and mood enhancing effects. Pectin is selected as the matrice to carry drug loaded MOFs. The main reason to chose pectin lies in its antibacterial properties and high capacity to absorb excess water in healing wound; therefore pectin will not remain inert to the surrounding.

With this motivation, nanosized MIL-100(Cr,Fe) and MIL-101(Cr,Fe) were prepared by both conventional hydro/solvothermal and microwave-assisted methods. Synthesized material were characterized by using XRD, TGA, SEM, N₂adsorption. Particle size analysis were also conducted on prepared materials. Procaine loading and releasing investigated at pH 6.4 since it is the pH of wound fluids, by using UV-visible spectrophotometer.

An outstanding drug loading (99.99 wt.%) was achieved for both MOFs, in less than 5 hours. Complete release of Procaine from MOFs occurred very quickly as a result of small size of drug molecules, fast drug dissolution and diffusion. It is observed that release of the drug from MOFs by preparing pectine-MOF mixed matrice.

The results show that MIL-100(Cr,Fe) and MIL-101(Cr,Fe) have potential to be used in patch preparation ultimately aimed to be used in topical treatment of inflammatory wounds.