(198ae) PVA –Based Nanostructuraed Catalysts Support Functionalized with Pyrrolylquinone-Tetrazole

The Organocatalysis has been of great importance in the last years and has focused on the development of efficient organic catalysts to get high yield to selectivity ratio and to promote transformations using substoichiometric quantities. Particularly, the selective oxidation of organic compounds is a great challenge in chemical synthesis, and active organic molecules are a feasible alternative as efficient catalyzers in the oxidation of organic compounds. In this context, the quinones are excellent agents for electrons transference and stand out as catalysts in oxidation reactions.

Recently, a new pirrolilquinone based molecule has demonstrate a great potential as organic catalyst in oxidative transformations. However, the catalysts recovery and recycling is often complicated, and has been a constant challenge to develop sustainable processes and strategies. The Immobilization of organocatalysts in polymeric nanostructured supports has been an outstanding strategy in the last years to overcome the problems associated to catalysts recovery and recycling. In addition, the high volume to surface area ratio of nanofiber supports provide a higher contact area, mimicking thus the homogeneous catalysts. The nanostructured polymeric supports offer several active sites; therefore, the organocatalyts can be incorporated in large quantities along the polymeric support, giving a wide variety of applications according to the reaction conditions.

Polyvinyl alcohol (PVA) is a highly attractive polymer for the production of nanostructured supports. Its physicochemical properties make PVA a versatile polymer for its processing through the electrospinning technique, obtaining high quality nanofiber collections. PVA can be functionalized through the formation of covalent bonds between the hydroxyl groups of PVA and the ligand through substitution or esterification reactions. This work present the synthesis of a polymeric nanostructured support for the immobilization of pyrrolylquinone-tretrazole organocatalyts, using the multicomponent reaction strategy Ugi-Azida; a sustainable and environmentally friendly approach.