(232c) Electrospray-Mediated Flash Nanoprecipitation for Synthesizing Drug Delivery Nanocarriers
AIChE Annual Meeting
2018
2018 AIChE Annual Meeting
Sustainable Engineering Forum
Nanomaterial Applications for Human Health and the Environment
Monday, October 29, 2018 - 5:36pm to 5:54pm
Inspired by previous FNP studies, we developed an FNP process that utilizes electrospray atomization to enable rapid mixing, as opposed to impinging jet flow. Liquid-Liquid Electrospray (LLE) is a technique in which, unlike conventional electrospray, a nonconductive solvent is atomized inside a more conductive solvent. Using LLE, water-miscible organic solvent (i.e. tetrahydrofuran) containing BCPs and hydrophobic therapeutics was sprayed into water, inducing atomization and rapid mixing. This resulted in an FNP process yielding highly monodisperse polymeric drug. Unlike traditional impinging jet approachces, the rapid mixing achieved in LLE-FNP is independent of flow rate because fluid atomization is primarily based on the applied voltage. Using this approach, we produced monodisperse polymeric nanocarriers (monodispersity ~ 0.07) encapsulating a variety of cancer therapeutics, including dexamethasone, vorinostat, and lutein; the encapsulation efficiency and drug release characteristics were examined (encapsulation efficiency ~ 30 - 70%).