(289e) Transport of Paramagnetic Nanoparticles in Magnetic Field for Drug Delivery
AIChE Annual Meeting
2018
2018 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
In Honor of Professor D. Ramkrishna's Contributions to Biopharmaceutical Industry (Invited Talks)
Tuesday, October 30, 2018 - 9:40am to 10:00am
Paramagnetic particles can be used as carriers to effectively transport drugs through cerebrospinal fluid and deliver to the targets using a magnetic field. Since the invivo experiments are expensive and difficult to conduct for such systems, a mechanistic model that can predict the dynamics and distribution of paramagnetic particles is necessary for the optimal design of drug delivery systems. The existing models are applicable to dilute solutions of paramagnetic particles and cannot be extended to concentrated solution, which is generally created near the magnetic targets. In this talk, I will present a framework to model magnetophoretic diffusion and convection of paramagnetic particles in a concentrated solution. An analytical solution to the magnetic field-driven transport of particles in 1-D will be discussed with application to drug delivery through cerebrospinal fluid.