(388c) Lab-on-Skin: Epidermal Microfluidic Device for the Capture, Storage, and Colorimetric Sensing of Sweat

The lack of a precision, intimate body interface in modern health related sensing and diagnostic devices frustrates reliable collection of clinical quality data. This presents a tremendous opportunity for developing devices that can fully integrate with the body, for diagnostic, therapeutic or surgical function with important, unique capabilities in clinical healthcare and biomedical research. In this talk, I will present the materials and device designs of skin-interfaced microfluidic system that can capture and analyze biomarkers of creatinine and urea in human sweat for the early detection of chronic kidney disease. Human studies demonstrated the functionality of this microfluidic device in a controlled environment. The results include quantitative values for sweat rate, pH, and concentration of urea and creatinine. The developed skin-interfaced microfluidic device provides new avenues for personal healthcare, medical diagnosis, and biological studies.