(531a) Transforming Layered Materials into Mechanically-Robust Fibers and Hydrogels
AIChE Annual Meeting
2018
2018 AIChE Annual Meeting
Materials Engineering and Sciences Division
Polymer Processing and Rheology
Wednesday, October 31, 2018 - 12:30pm to 1:00pm
Recent innovations in multilayer co-extrusion technology have translated to the fabrication of melt-extruded polymeric rectangular fiber mats and composites. Distinct advantages of this modular approach over other traditional fiber processing techniques include scalability, environmentally-friendly conditions, and the ability to obtain cross-sectional dimensions on the nanoscale. Here, we describe the mechanics and structural features of biologically-relevant, high surface area fiber mats. Functional fiber substrates were obtained via facile surface modification and inclusion of therapeutics. We also focus on this fiber technology as a new platform for the development of reinforced hydrogels via an in situ approach. This manufacturing strategy allows for strategic control of hydrogel architecture, fiber alignment and loading, compressive stability and stiffness. Promising results related to cell adherence and growth are highlighted for these extruded hydrogel scaffolds.