(66b) Biohybrid Microswimmers with Biocompatible Polymetric Multilayers as Drug Delivery System
AIChE Annual Meeting
2018
2018 AIChE Annual Meeting
Liaison Functions
Biotechnology & Materials U.G. Research Session (Invited Talks)
Monday, October 29, 2018 - 8:25am to 8:50am
In addition, responsiveness plays an important role in delivery applications, either for therapeutic loading or efficient drug release. We have developed bacteria-driven microswimmers with biocompatible polymeric construction and demonstrated their performance in a microfluidic device to develop a new type of biohybrid microsystem. The microswimmers are composed of single gram-negative bacterium attached to the outermost layer of drug-loaded biocompatible microparticles incorporated with layer-by-layer (LbL) polyelectrolyte multilayer (PEM) and Escherichia coli. The results show that these biocompatible microswimmers can move in various medium conditions and play the combined role of microsensor, microactuator, and therapeutic payload, indicating a great potential for targeted active drug delivery systems.