(66e) A New Way to Model the Brain: The Flow Limiting Operator

The challenge of creating more realistic bioreactors has been an increasing endeavor, particularly when applied to the brain. These model systems allow for new biomaterials to be rigorously tested at low cost, but at the cost of losing entire cascades and being able to study their effects on the object in question. In our previous assessment of biomaterials used in the brain, different flow rates lead to varying cell attachment rates (Harris et al., 2011). Current brain models can either accurately mimic flow rate of cerebral spinal fluid, pulsation of the venous system, or the opening pressure of ventricles. However, many systems use only a combination of these factors and those that incorporate all these variables use static values. Our proposed model is a cost effective, easy to use Arduino-based system which can manipulate both flow and pressure throughout the day, similarly to inherent changes from physiologic conditions of circadian rhythm or physical activity. By creating multiple if/then commands and receiving data from peripheral sensors, the Arduino can self-manipulate the conditions of strategically placed stepper motors and pumps to manipulate pressure and flow rate. In future work, flow and pressure can be modeled for the heart, liver, or kidneys. This system relies on manually programming desired pressures to the Arduino, but future improvements can also include implementing patient data in real time from various other systems to give an even greater holistic view of the human body.