(146e) Highly Selective Ultrafiltration – Exploiting Non-Steric Interactions for Bioprocessing

Ultrafiltration is a well established method for protein concentration and buffer exchange. Nearly all current biotherapeutics are formulated using ultrafiltration / diafiltration processes. However, recent advances in our understanding of membrane transport phenomena has led to exciting opportunities for the development of highly selective ultrafiltration processes for bioseparations. This talk will review these developments and how they have been used to develop membrane systems for the purification of conjugated vaccines and nucleic acid-based gene therapy agents. These results clearly demonstrate the significant potential of using ultrafiltration membranes for the commercial production of next generation biotherapeutics.