(182b) Evaluation of Nano-Metal Organic Frameworks Safety through Transpiration and Translocation in Celery (Apium graveolens)

Bio-nanomaterials have been gaining attention and investments, with a projected €100 billion global market by the year 2020. They are of great interest because of the medical needs of the ageing population. Bio-nanomaterials are very essential as they are used in advanced therapy medicinal products and medical devices, which aid in drug delivery. However, several bottlenecks negatively affect the market. Thus, the main goal of this research is to remove these bottlenecks. This research will focus on metal-organic framework (MOF). The goal of this study is to form the smallest MOF possible. In addition, the functionality of the metal organic framework will be engineered at molecular level to obtain different hydrophobic characteristics. To verify the full safety of the synthesized nano-MOFs, several criteria will be considered. First, the organic ligands which will be functionalized must have low toxicity based on available statistics and findings. Secondly, the metal to be selected must be rare in the environment, so that all false positive results from contamination will be eliminated. Safer-by-design and safe-production of bio-nanomaterials will be achieved by following standard operating procedures in synthesizing MOFs. Finally, transpiration and translocation of metal organic frameworks in celery will be studied to know its implication in the inhalation and consumption safety to humans.