(221n) Effects of Internal Structures on Capsule Lateral Migration

Even though the interfacial dynamic of simple capsules representing healthy biological cells such as RBC is well understood, more complicated systems involving complex inner structures are need to be studied. Several investigations have considered the effects of physical properties including viscosity ratio, membrane elasticity, and flow rates on the dynamics and deformation of simple physiological capsules. However, owing to disease progress, in many cases, some cells undergo significant changes that may alter their inner structures, i.e. malaria-infected red blood cells. Such changes in the inner structures of cells affect their hydrodynamic behavior.

The present work considers the effects of inner structure on the overall deformation and hydrodynamic of capsules. We utilize our membrane spectral boundary integral method to model an ill cell with a nucleolus as a double-layer capsule. We will present the effects of physical parameters on double-layer capsule migration. We further compare our results with lateral migration of a simple capsule. Our study provide insights for early detection of diseases and design of cell sorting devices that facilitates rare cell isolation.