(380x) Overcoming the Limitations of Hydrochlorothiazide Micronization Using the Precipitation with Compressed Fluid Antisolvent Process
AIChE Annual Meeting
2019
2019 AIChE Annual Meeting
Particle Technology Forum
Poster Session: Particle Technology Forum
Tuesday, November 12, 2019 - 3:30pm to 5:00pm
To overcome these restrictions, this research utilized the precipitation with compressed fluid antisolvent process under sub-and supercritical conditions. The model drug, Hydrochlorothiazide(HCT), is classified as poorly soluble by the Biopharmaceutics Classification System. Miconization of neat HCT yielded agglomerated, irregular microparticles. While the particle size decreased, not much difference was observed in the dissolution rate. Therefore, to further decrease the particle size, HCT was coprecipitated with a water soluble polymer, polyvinylpyrrolidone (PVP). As a result, uniform, spherical nanoparticles that significantly enhanced the dissolution rate of HCT were obtained. FT-IR results show no sign of residual solvent, which is crucial for the drugâs stability and toxicity. A combination of HR-TEM and the dissolution tests revealed that the particles are composed of PVP particles that contain HCT. Even though an excipient was used, the products showed high normalized drug loadings and precipitation yields. These results suggest that HCT particles precipitated on the PVP particles by heterogeneous nucleation.