(499b) Automated Nanomole-Scale Platform for Rapid Screening and Optimization of Electroorganic Synthesis
AIChE Annual Meeting
2019
2019 AIChE Annual Meeting
Pharmaceutical Discovery, Development and Manufacturing Forum
Advances in Drug Discovery Processes
Wednesday, November 13, 2019 - 12:55pm to 1:20pm
Electroorganic synthesis has recently emerged as a powerful tool for synthetic chemists to access unprecedented transformations under mild, and environmentally friendly conditions. However, the vast parameter space and prolonged reaction time of electroorganic synthesis create challenges to discover, optimize, and understand newly developed electrochemistry.
Here, we demonstrate a fully automated droplet-based screening platform to enable rapid examination of the electrochemical reactions with nanomole amount of reagents, which can potentially facilitate the mechanistic understanding of the electrochemical systems. This platform achieved 10-fold increase in screening throughput compared to traditional batch screening approach. Electrochemical radical cross-coupling reactions are examined on this system. Additionally, we demonstrate the optimal electrochemical reaction condition obtained from the screening platform can be directly applied to the large-scale electrosynthesis to quickly access the desired substrate.