(560is) Mechanism of Effluence of Internal Substance from Pluronic Micelles By External Stimuli

Process intensification has attracted much attention in the field of chemical engineering since the 2000s. Stankiewicz and Moulijn defined process intensification as “Any chemical engineering development that leads to a substantially smaller, cleaner and more energy efficient technology,” and it can be categorized into two classes: equipment and methods. In a general chemical industry, many reactors, mixture operations, and separation operations are needed to produce chemical product, and the design and maintenance become complex. On the other hand, high performance drug carrier such as polymer micelles has been investigated in the field of drug delivery system. In this study, the application of the drug carrier to a chemical reaction process was investigated from the view point of process intensification. Pluronic micelle and hydrophobic dye were used as a model reactant carrier and internal substances, respectively. The effects of ultrasonic irradiation on effluence of internal dye from Pluronic micelles were investigated. Moreover, the effects of radical scavenger addition on the effluence of dye was also investigated to consider a mechanism of effluence of internal substance from Pluronic micelles. For comparison, the effect of thermal stimulation on the release of dye was also investigated. A Pluronic micelle solution containing NKX-1595 was prepared by a dialysis method. The sample was irradiated with ultrasound for 10 min, and the effects of ultrasonic frequency, power, and radical scavenger addition on the effluence of the dye were investigated. The internal dye was rapidly released from the micelle at low ultrasonic frequencies, and radical scavenger addition was not influence the effluence of dye. Therefore, ultrasonic physical effect is considered one of the main factors. In addition, we investigated the effects of thermal stimulation on effluence of dye at several environmental temperatures. The internal dye was gradually released from the micelle when the environmental temperature was higher than 303 K.