(593h) Micro-Chemical Technology Tune Nanoscale Structure of Nanoparticles and Its Bioapplication

Nanoparticles have been extensively studied due to their wide application, especially in the area of bio-medicine, including drug-carrier, targeting delivery, imaging, etc. Recently, the systematic regulation of nanostructure has attracted considerable research interests, as it is found that to achieve optimum accumulation of nanotherapeutics specifically at diseased sites, not only the sizes but the nanoscale structure also need to be optimized. In this study, the micro-structure of nanomaterials (including external structure, internal structure) have been systematically tuned by a micro-chemical technology, named Flash Nanoprecipitation (FNP). Through tuning the polymer concentration, the external structure (shape) could be controlled from nano-rod, to micro-rod and nano-sphere. In vivo experiment exhibit that the nanorod particles with a polymer shell display excellent tumor targeting capability. In addition, through tuning stream velocity, the internal structure could also be controlled from compact to loose formation. In vitro drug release show that the compact formation has a relatively lower release velocity. Therapeutic and imaging applications may therefore benefit from the strategy adopted here.