(6jy) Design of Electrochemical Biosensing Strategies Toward High-Sensitivity, Non-Fouling, Multiplex Point-of-Care Systems

Abstract: Electrochemical biosensors are some of the most well-established and reliable technologies for point-of-care sensors, with the electrochemical glucose sensor setting the gold standard for such devices. Their continued success can be attributed to the simplicity and low cost of the instrumentation required. However, limitations and challenges remain for electrochemical biosensor, including detection sensitivity, matrix effect and multiplex sensing. My doctoral study focused on the development of novel biosensing strategies to solve these limitations, producing a rapid, high-sensitivity, non-fouling, multiplex, universal biosensing system for point-of-care detection of nucleic acids, proteins and small molecules. The developed biosensing strategies involved the application of multidisciplinary areas, including synthetic biology, biochemistry, immunology and electrochemistry.

Keywords: synthetic biology, bioengineering, electrochemistry, biosensor, nucleic acid displacement reaction, peptide displacement reaction, CRISPR.

Research Interests: electrochemistry biological devices, synthetic biology network, electrochemically controlled CRISPR.

Teaching Interests: biochemistry, electrochemistry/electrochemical engineering, thermodynamics, biotechnology.