(790j) Spray Drying of Griseofulvin Nanosuspensions and Solutions for Preparation of Nanocomposites and Amorphous Solid Dispersions: Comparative Assessment of Drug Release
AIChE Annual Meeting
2019
2019 AIChE Annual Meeting
Liaison Functions
MAC Eminent Engineers Awards Poster Session
Monday, November 11, 2019 - 5:30pm to 6:00pm
GF nanocomposites were prepared by wet media milling (nanomilling) an aqueous GF suspension followed by spray drying. Two different polymers, hydroxypropyl cellulose (HPC) and Soluplus, with an anionic surfactant, sodium dodecyl sulfate (SDS), were used for the stabilization of drug nanoparticles. ASDâs were formulated by spray drying the respective drug-polymer in acetone-DI water. The suspensions were characterized via laser diffraction, while the spray-dried powders were characterized via laser diffraction, X-ray diffraction (XRD), and dissolution testing. XRD diffractograms confirmed that for both polymers, spray drying of the aqueous nanosuspension led to nanocomposites, whereas that of the drug solution led to ASD. At supersaturating conditions, drug dissolution from ASD was faster than that from the nanocomposites.