(173e) Continuous Crystallization of Systems Prone to Oiling out - Leveraging Phase Diagrams

Recent years have seen an increased thrust in process research and development with a focus on continuous manufacturing processes for pharmaceutical and agrochemical molecules. To that end, we have been developing novel continuous crystallization schemes that facilitate increased throughput, improved process reliability, and reduced capital and operational costs. In this work we discuss a continuous crystallization technique applicable to molecular systems prone to oiling out. We leverage the knowledge of phase diagrams for these systems and generate crystals of different physical characteristics by operating the process at different locations of the phase diagram. Rather than avoiding oiling out (as usually desired in traditional batch processes), we actively trigger the liquid-liquid phase separation of the systems in short time scales to enable rapid crystallization, thus producing particles of different sizes and textures. From these results, the relation between the location of the process on the phase diagram and the nature of resulting particles is explored. These results pave the way toward developing intensified continuous crystallization processes through experimental and modeling approaches.