(30t) Next generation nano-diagnostic devices: Graphene interaction with skin cancer cells

In this study, we exploit the remarkable properties of graphene, a versatile two-dimensional nanomaterial, to discern and differentiate between cancerous and normal tissues through subtle modifications in graphene's characteristics. The inherent sensitivity of graphene's zero-band structure to doping phenomena, stemming from interactions with surrounding materials, forms the foundation of our approach. Leveraging this phenomenon, we investigate the distinct Raman spectral features of graphene, specifically the 2D and G bands, which exhibit distinctive blue or red shifts contingent upon the nature of doping. Through a meticulously designed 3D-printed platform, graphene is meticulously interfaced with basal cell carcinoma (BCC), squamous cell carcinoma (SCC), melanoma, and normal skin tissues on glass slides. Notably, our investigation of graphene's Raman spectra reveals a profound shift in the 2D band for normal versus cancerous tissues, underscoring its potential as a discriminatory diagnostic tool. This assertion is substantiated by consistent findings across 4 BCC, 4 SCC. Our work holds profound implications for non-invasive and precise cancer diagnosis, heralding a new era in early detection and personalized therapeutic interventions.