(337ct) Continuous Crystallization Process Design Towards Improved Purity and Solid Forms

In pharmaceutical and chemical industry, synthesizing solids with simultaneous high purity and proper solid forms is desired for process efficiency and product consistency, but often challenging to achieve.^1–4 This poster presents a simple continuous purification process based on crystallization, using a model active pharmaceutical ingredient. Practical operational issues are also discussed.

Reference

(1) Variankaval, N.; Cote, A. S.; Doherty, M. F. From Form to Function: Crystallization of Active Pharmaceutical Ingredients. AIChE J. 2008, 54 (7), 1682–1688.

(2) Jiang, M.; Braatz, R. D. Integrated Control of Continuous (Bio)Pharmaceutical Manufacturing. Am. Pharm. Rev. 2016, 19 (6), 110–115.

(3) Mozdzierz, N. J.; Lee, Y.; Hong, M. S.; Benisch, M. H. P.; Rasche, M. L.; Tropp, U. E.; Jiang, M.; Myerson, A. S.; Braatz, R. D. Mathematical Modeling and Experimental Validation of Continuous Slug-Flow Tubular Crystallization with Ultrasonication-Induced Nucleation and Spatially Varying Temperature. Chem. Eng. Res. Des. 2021, 169, 275–287.

(4) Zambrano, C. D. P. V.; Jiang, M. L-Glutamic Acid Crystals of Pure α Form and Uniform Size Distribution from Continuous Non-Seeded Reaction Crystallization in Slug Flow. CrystEngComm 2023, Advance Article.