(349h) The Effect of Sulfur on the Antibacterial Properties of Metal Organic Frameworks Prepared from Succinic Acid Derived Organic Linkers with Co(II), Ni(II), and Cu(II) Metal Ions

Here, metal organic frameworks from succinic acid (SA, C₄H₆O₄), mercaptosuccinic acid (MSA, C₄H₆O₄S), and dimercaptosuccinic acid (DMSA, C₄H₆O₄S₂) using different metal ions such as Co(II), Ni(II), and Cu(II) were prepared. The role of the thiol groups on the antibacterial properties of the corresponding MOFs were determined by testing the antibacterial properties of the prepared MOFs on various microorganism. In the antimicrobial studies, broth micro-dilution, and disc diffusion methods were used to test the prepared MOFs against Escherichia coli (E. coli, ATCC 8739) and Pseudomonas Aeruginosa (P. aeruginosa, KWIK-STIK 0693X) as a gram-negative, Staphylococcus aureus (S. aureus, ATCC 6538) and Bacillus subtilis (B. subtilis, ATCC 663) as a gram-positive bacteria and Candida Albicans (C. albicans, ATCC 10231) as a fungus. The biocompatibilities of the prepared MOFs on L929 fibroblast cells were investigated in vitro via MTT tests. It was demonstrated that SA-based MOFs are versatile and have many potential biotechnological applications as antibacterial filling materials including biomedical, cosmetics, food packing, and agricultural fields.

Acknowledgments

This work is supported by Canakkale Onsekiz Mart University Scientific Research Commission (COMU-BAP: FHD-2021-3700).