(376b) Antimicrobial Fluorescent Covalent Organic Frameworks

Fluorescent covalent organic frameworks (COFs) derived from perylene-3,4,9,10-tetracarboxylic dianhydride (PTCDA) and various amine sources such as tris(2-amino ethyl)amine (TAEA), pentaethylenehexamine (PEHA), branched polyethyleneimine (B-PEI), and linear poly(vinyl amine) (L-PVAm) as antibacterial materials. The structural, morphological, optical, and thermal characterization of PTCDA-based COFs were done using Fourier Transform-Infrared Radiation (FT-IR) spectroscopy, fluorescence spectroscopy, scanning electron microscope (SEM), thermogravimetric analyzer (TGA), respectively. The porosities of the prepared PTCDA-based COFs were examined via Brunauer-Emmett-Teller (BET) method and surface area, and porosity analysis such as pore volume and pore size were also evaluated through Barret-Joyner Halenda (BJH) method. The antimicrobial activities of synthesized PTCDA-based COFs were investigated against Gram-negative bacteria, Escherichia coli ATCC 8739 and Pseudomonas aeruginosa (KWIK-STIK 0693X), and Gram-positive bacteria such as Bacillus subtilis ATCC 6633, Staphylococcus aureus ATCC 6538, and a yeast, Candida albicans ATCC 10231. It was shown that fluorescent PTCDA-based COFs with antibacterial properties possess interesting biotechnological applications.