(410e) Engineering Precision Bottlebrush Polymers with Tailored Ionic and Hydrophobic Side Chains for Enhanced Solubilization and Improved NMR Dynamics

In this talk, we will present the design and synthesis of precision bottlebrush polymers featuring sequence-defined ionically charged and hydrophobic side chains. By carefully controlling the sequence and chemical composition of hydrophilic side chains, highly hydrophobic fluorine-rich moieties can be fully solubilized and their NMR dynamics modulated. Notably, the importance of side chain design, among other structural parameters, underlines the significance of precision synthesis on NMR signal-to-noise ratio, signal broadness, and potentially MR image contrast enhancement. Apart from materials for sensing applications, precision polymer-based amphiphiles also display significant promise as multifunctional additives and interfacial stabilization agents.