(452e) Ionic Drug Transport in Charged Ion-Exchange Biosponge Adsorbers to Reduce Chemotherapy Toxicities
AIChE Annual Meeting
2023
2023 AIChE Annual Meeting
Materials Engineering and Sciences Division
Charged and Ion-Containing Polymers: Membranes and Interfaces
Tuesday, November 7, 2023 - 9:15am to 9:30am
In the context of reducing the toxicity of chemotherapy, we have designed charged ion-exchange biosponge adsorbers for capturing ionic chemotherapy drugs before they spread through the body. Doxorubicin, a widely used chemotherapy drug with significant toxic side effects, is a model drug. The charge concentration and water uptake in the biosponge adsorbers are systematically changed to achieve high binding capacity and fast kinetics. We aim to understand the mechanism of ionic drug transport in these biosponge adsorbers and design highly selective polymers in the presence of competing species in blood. Using a swine model, our initial design enables the capture of 69 % of the administered drug without any adverse effects. The proposed approach may help patients fight cancer.