(456b) Scale up/Scale Down of Impulse Mixer Using CFD
AIChE Annual Meeting
2023
2023 AIChE Annual Meeting
North American Mixing Forum
Mixing Scale-Up and Scale-Down Issues in Pharmaceutical & Biopharmaceutical Processes
Wednesday, November 8, 2023 - 8:30am to 9:00am
From a modeling standpoint, they do pose unique challenges though. The continuously changing geometry because of the mixer oscillation requires the implementation of a moving and deforming (MDM) technique that must be both efficient (i.e., allow for fast simulation) and maintain good accuracy for the eventual species mixing part of the simulation (i.e. avoid numerical diffusion). An additional complexity that is inherent to imPULSE mixers is the presence of âflapsâ within the mixers that âopenâ during the upward stroke and âcloseâ during the downward stroke. This on-off behavior of the flaps augments the effect of the mixer motion on the flow field within the vessel and enhances the mixing process.
In this current work, we will present a novel way to represent the presence of the flaps using a porous media approach. The porous media representing the presence of the flaps will have a time varying flow resistance that drops to zero during the upward stroke and has an artificially high value during the downward stroke. In addition, the âmesh layeringâ technique will be used to re-mesh the domain as the mixer oscillates. It is also noted that this method is the most efficient and accurate among re-meshing techniques and is ideal for oscillatory motion in general.
Finally, three different scales will be simulated and compared using the proposed approach, namely the current size of 5,000-L, 3,000-L, and a 250-L size with respect to their P/V and blend time.