(485f) Process Intensification Technologies Using in-Line Concentrators for High Titer Mab Process

As mAb titers are increasing, its straining downstream purification manufacturing technologies. One of the issues facing manufacturing is the ever increasing in-process volumes, due to increasing titers. In this case study we would look at comparative evaluation of Single Pass Tangential flow filtration (SPTFF) or In-line product concentrators technologies for the there management of in-process volumes for downstream process fit. Comparative evaluation of SPTFF technologies on in-process volume controls including process robustness and controlling parameters, product quality impact, manufacturing scalability and implementation is discussed.