(55b) Innovation in Downstream Processing: Next Generation Solutions and Need for Speed

The field of biotherapeutics has been developing quickly– our pipelines have been greatly diversified over the last few years to include different hosts, multi-specific antibodies and antibody-drug conjugates, nanobodies, synthorins relying on an expanded genetic code, gene and cell therapies, enzymes, vaccines and mRNA. In addition, during the COVID-19 pandemic, we have experienced the need to perform process development and to solve very challenging problems in the fast lane. This diversity and the need for speed have been driving the need for innovation, next generation solutions and new ways of working in downstream processing. In this presentation, we will cover the innovation in downstream processing focusing on advances in process development including modeling-aided development, new purification technologies and new modes of operation. We will cover these aspects with industry-wide examples and Sanofi-specific case studies.