(608a) Preparation and Characterization of Sponge-like Cryogel Particles Modified with Phospholipid Bilayer Membrane

In the design and development of the chemical process, it is important to improve the efficiency and selectivity of the separation process. In order to keep high separation efficiency and selectivity, it is essential to optimize the separation process at the macroscopic scale and, furthermore, to control the physicochemical properties of the core materials for separation at the meso/micro scale and. It is therefore important to focus on the utilization of “self-organized system of the molecules”; for example, it can be achieved via the integration of the ordered phospholipid membranes and cryogels with large porosity and sponge-like elasticity. From the macroscopic viewpoint, it was focused on substrate material which have elasticity and porous structure for modification self-assembly molecules such as lipid membrane. Subsequently, from the microscopic viewpoint, the lipid membrane which is highly-ordered by self-assembly was selected as the modified of the polymer particle because it has potential which can manipulate their properties via mechanical stimulation. The purpose of this study is to separate cryogel particles modified with phospholipid membranes by using mechanical stimuli as a driving force. A method for preparing polymer particle carriers with elasticity that is easy to process and manipulate is established. Furthermore, the method of modifying the polymer surface with phospholipid membranes is systematically discussed. Based on these findings, a method of modification of polymer surfaces by phospholipid membranes was established. The possibility of using the modified phospholipid membranes as advanced separation materials is demonstrated by controlling the properties of the membranes via mechanical stimulation.

[Ref] ACS Applied Polymer Materials, 4(10), 7081-7089 (2022) / ACS Omega, 8(1), 829-834 (2023).