(630e) The Additives to PLGA Nanoparticles – Influence of the Glass Transition Temperature on Drug Release Behavior
AIChE Annual Meeting
2023
2023 AIChE Annual Meeting
Materials Engineering and Sciences Division
Polymer Thin Films, Confinement, and Interfaces
Thursday, November 9, 2023 - 9:30am to 9:45am
In this study, we aim to examine the impact of Tg of PLGA nanoparticles in two aspects: surfactant and loaded drug. To minimize the Tg increase from a secondary component in the particle matrix, we have opted for a non-polymeric surfactant, didodecyl dimethyl ammonium bromide (DMAB), as an alternative stabilizer during PLGA nanoparticle preparation, and compared its efficacy with that of the commonly used surfactant, polyvinyl alcohol (PVA). Our results showed that the Tg of both PVA and DMAB stabilized particle and bulk samples measured in wet conditions is significantly lower compared to that in dry conditions when residual surfactant is present, except for bulk PLGA containing DMAB. This observation may be attributed to the plasticizing effect of small surfactant molecules. Importantly, the Tg of particles in wet conditions is approaching physiological temperatures, where even minor variations in Tg could have a significant impact on drug release behaviors.
Additionally, flurbiprofen (FBP) was used as a model drug to investigate its plasticizing effect on PLGA nanoparticles. Our finding indicates that an increased drug loading efficiency of PLGA nanoparticles leads to reduction in Tg of the nanoparticles, which is in agreement with previous studies. Results from a release study of FBP-loaded PLGA particles will also be presented.