(636a) Opportunities of Enabling Technologies in Sustainable Development of Pharmaceutical Processes

The emergence of enabling technologies has greatly improved the efficiency of pharmaceutical process development and manufacturing over the past decade. This study focuses on the opportunities presented by these technologies in sustainable development, particularly in reducing process mass index, wastes, and process hazards. A model deployed at AbbVie is shared, which accelerates the understanding, adoption, and implementation of enabling technologies from laboratory proof of concept to large-scale cGMP manufacturing. Case studies on centrifugal extractors, flow hydrogenation, inline water removal using molecular sieves, and pervaporation are presented to showcase the potential of enabling technologies in improving the process, environment, and operator health and safety. Overall, this study highlights the significant impact of enabling technologies on advancing sustainable development in the pharmaceutical industry.

Disclosures:

All authors are employees of AbbVie. The design, study conduct, and financial support for this research was provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the publication.